Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure
نویسندگان
چکیده
منابع مشابه
Lamivudine plus adefovir combination therapy for lamivudine resistance in hepatitis-B-related hepatocellular carcinoma patients
BACKGROUND/AIMS Lamivudine (LAM) plus adefovir (ADV) combination therapy has been accepted as one of the best treatments for LAM-resistant chronic hepatitis B (CHB). The aim of this study was to determine the efficacy of this combination therapy in hepatocellular carcinoma (HCC) patients. METHODS The medical records of CHB patients who developed LAM resistance and were treated with LAM plus A...
متن کاملThe feasibility of discontinuing lamivudine in lamivudine-resistant chronic hepatitis B patients on lamivudine and adefovir combination therapy.
OBJECTIVES This study investigated the antiviral efficacy of adefovir (ADV) rescue therapy and the feasibility of lamivudine (LAM) discontinuation in LAM-resistant chronic hepatitis B (CH-B) patients who had attained a virological response (VR) with LAM + ADV combination therapy. METHODS The VR and virological breakthrough (VBT) were analyzed in 106 consecutively enrolled LAM-resistant CH-B p...
متن کاملTwo years efficiency of lamivudine and adefovir dipivoxil combined therapy in chronic hepatitis B patients.
BACKGROUND Lamivudine (LAM) and adefovir (ADV) are widely used in most Asian countries, though monotherapy is associated with the occurrence of resistance. AIM To evaluate the efficiency of LAM and ADV combined treatment of chronic hepatitis B patients with compensated cirrhosis. PATIENTS AND METHODS 206 eligible Chinese patients were randomly assigned in a 1:1 ratio to receive either LAM o...
متن کاملA novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
AIMS This study was conducted to clarify the resistance profile of a novel mutation pattern emerging during lamivudine (3TC) therapy and showing cross-resistance to adefovir dipivoxil (ADV) in a patient with chronic hepatitis B. METHODS AND RESULTS Successful suppression of hepatitis B virus (HBV) replication by sequential therapy of 9 MU thrice weekly interferon (IFN) and 3TC was followed by...
متن کاملEfficacy of Adefovir - based Combination Therapy for Patients with 1 Lamivudine - and Entecavir - Resistant Chronic Hepatitis
Authors: 6 Yun Bin Lee (e-mail: [email protected]) 1 7 Jeong-Hoon Lee (e-mail: [email protected]) 1 8 Won-mook Choi (e-mail: [email protected]) 1 9 Young Youn Cho (e-mail: [email protected]) 1 10 Jeong-ju Yoo (e-mail: [email protected]) 1 11 Minjong Lee (e-mail: [email protected]) 1 12 Dong Hyeon Lee (e-mail: [email protected]) 1 13 Yuri Cho (e-mail: [email protected]) 1 14 Su J...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2005
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2004.09.017